The use of aspirin is associated with an increased risk of heart failure in patients who have a predisposing factor, such as smoking, obesity, high blood pressure, high cholesterol, diabetes and cardiovascular disease this is the conclusion of a study published in
«ESC Heart Failure».
“This is the first study to analyze whether people with at least one risk factor, who take aspirin, are more likely to suffer from heart failure than those who do not take it,” says the study author, Blerim Mujaj of the
University of Freiburg (Germany).
The author adds that “although the results require further study, they indicate that the potential link, between aspirin and heart failure needs to be clarified».
The research aimed to evaluate the relationship of aspirin with the incidence of heart failure in people with and without heart disease and to see if the use of the drug is related to a new diagnosis of heart failure in people at risk.
The study included 30,827 people at risk of developing heart failure who were included in the study HOMAGE from Western Europe and also developed in the US Participants were 40 years of age or older and did not have heart failure at baseline, although some did have a predisposition for risk factors. The average age of the participants was 67 years and 34% were women.
Each of them underwent a clear follow-up and each case of heart failure was recorded in its different degrees, mild, severe and required hospitalization.
At the start of the study, a total of 7,698 participants (25%) were taking aspirin. During the 5.3 years that the study lasted, an estimated 1,330 participants developed heart failure.
The researchers evaluated the association between aspirin use and heart failure after having shuffled data such as; sex, age, body mass index, smoking, alcohol consumption, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease and treatment with renin inhibitors of the angiotensin-aldosterone system, channel blockers calcium, diuretics, beta-blockers, and lipid-lowering drugs.
To verify the consistency of the study, the results were repeated between aspirin users and non-users. Even to further contrast the results, the analysis was repeated after excluding patients with a history of cardiovascular disease.
22,690 participants (74%) were found to be free of cardiovascular disease, yet aspirin use was associated with a 27% increased risk of incident heart failure.
“This is the first large study to investigate the relationship between aspirin use and incident heart failure in people with and without heart disease and at least one risk factor. More trials in adults at risk for heart failure are needed to verify these results. Until then, our observations suggest that aspirin should be prescribed with caution in people with heart failure or with risk factors for the condition, ”says Mujaj.